Model System researchers use videos to communicate health information to people with spinal cord injury (SCI), traumatic brain injury (TBI), and burn injury and their caregivers. This guide provides tips for developing videos that are based on the best practices and experiences of the Model Systems Knowledge Translation Center (MSKTC) in producing hot-topic module videos. The guide outlines a four-stage process for video production, including conceptualizing the video, assembling the team to produce the video, and technical considerations.