Model System:

Burn

Reference Type:

JA

Accession No.:

Journal:


Journal of Burn Care & Research

Year, Volume, Issue, Page(s):

, 28, 3, 447-450

Publication Website:

Abstract:

Heterotopic ossification (HO) is a well-recognized complication of burn injury that can result in significantly compromised limb function. The etiology and optimal treatment strategy for HO remain elusive. The purpose of this study was to examine the relationship between delay in elbow wound closure and the development of HO. We performed a case-control study to examine the relationship between delay in wound closure and development of HO. Cases (HO patients) were identified using our patient registry and matched with patients of similar age, burn size, and sex who did not develop HO. Time to wound closure was compared using bivariate statistics and the odds for developing HO based on time to wound closure was modeled using multivariate logistic regression. During the study period, a total of 45 patients developed elbow HO. When compared with controls matched for age, burn size, and sex, elbow wounds were open significantly longer in the cases than in the controls (48.7 days vs 24.2 days, P <.01 on="" multivariate="" logistic="" regression="" the="" adjusted="" odds="" ratio="" was="" ci="" p="" time="" to="" elbow="" wound="" closure="" significantly="" impacts="" risk="" of="" development="" heterotopic="" ossification.="" therefore="" minimize="" ho="" formation="" increased="" attention="" is="" warranted="" optimize="" over="" joints.="" in="" addition="" consideration="" other="" soft="" tissue="" coverage="" options="" such="" as="" local="" flaps="" including="" fascia="" or="" muscle="" may="" be="" cases="" very="" deep="" buns="" with="" high="" skin="" graft="" failure.="">

Author(s):


Klein, MB., Logsetty, S., Costa, B., Deters, L., Rue, T.C., Carrougher, G.J., Pickens, M., Engrav, L.H.

Participating Centers: