Model System:
BurnReference Type:
JAAccession No.:
Journal:
Wound Repair Regen
Year, Volume, Issue, Page(s):
, 18, , 277-283Publication Website:
Abstract:
Autografting of burn wounds results in generation of donor site wounds. Here we measured donor site wound protein fractional synthesis rate (FSR) in a burn pediatric population and showed that FSR increases over time postsurgery and correlates with the length of hospital stay (LOS) normalized for total body surface area (TBSA) burn size. 3.9 +/- 1.1 days after the grafting surgery patients participated in a metabolic study consisting of continuous infusion of l-[ring-(2)H(5)]-phenylalanine and donor site wound punch biopsies. Donor site wound protein FSR was 10.4 +/- 7.5%/day. Wound FSR demonstrated linear correlation with the time postsurgery (p
Author(s):
Demidmaa, T., Chinkes, D.L., Zhang, X., Aarsland, A., Herndon, D.N.