Model System:

Burn

Reference Type:

JA

Accession No.:

Journal:


Burns

Year, Volume, Issue, Page(s):

, 31, 1, 10-May

Publication Website:

Abstract:

Despite decades of research, our understanding of human hypertrophic scar is limited. A reliable animal model could significantly increase our understanding. We previously confirmed similarities between scarring in the female, red, Duroc pig and human hypertrophic scarring. The purpose of this study was to: (1) measure vascular endothelial growth factor (VEGF) and nitric oxide (NO) levels in wounds on the female Duroc; and (2) to compare the NO levels to those reported for human hypertrophic scar. Shallow and deep wounds were created on four female Durocs. VEGF levels were measured using ELISA and NO levels with the Griess reagent. VEGF and NO levels were increased in deep wounds at 10 days when compared to shallow wounds (p

Author(s):


Zhu, K.Q., Engrav, L.H., Armendariz, R., Muangman, P., Klein, M.B., Carrougher, G.J., Deubner, H., Gibran, N.S.

Participating Centers: