Model System:

Burn

Reference Type:

Journal

Accession No.:

J73527

Journal:


Burns

Year, Volume, Issue, Page(s):

, 40, 3, 428-4235

Publication Website:

Abstract:

Study investigated whether systemic glucose levels over 150 milligrams per deciliter (mg/dl) in severely burned pediatric patients lead to an overwhelming growth of bacteria in the bronchopulmonary system, subsequently resulting in an increased risk of pulmonary infections. One-hundred six severely burned pediatric patients were enrolled in the study. Patients were divided in two groups: (1) high group, defined by daily average glucose levels greater than 150 mg/dl for more than 75 percent of the length of stay (LOS); and (2) low group, with daily average glucose levels less than 150 mg/dl for more than 75 percent of the LOS. Incidences of pneumonia, atelectasis, and acute respiratory distress syndrome (ARDS) were assessed. Incidence of infections, sepsis, and respiratory parameters were recorded. Blood was analyzed for glucose and insulin levels. Statistical analysis was performed using Student’s t-test and chi-square test. The 2 patient groups were similar in demographics and injury characteristics. Pneumonia in patients on and off mechanical ventilation, as well as ARDS were significantly higher in the high group, while atelectasis was not different. Patients in the high group required significantly longer ventilation compared to low patients. Furthermore, incidence of infection and sepsis were significantly higher in the high group. The results indicate that systemic glucose levels over 150 mg/dl are associated with a higher incidence of pneumonia, confirming the previous studies in critically ill patients.

Author(s):


Kraft, Robert, Herndon, David N., Mlcak, Ronald P., Finnerty, Celeste C., Cox, Robert A., Williams, Felicia N., Jeschke, Marc G.

Participating Centers: