Efficacy of Treatment of Major Burns with Anabolic Agents and/or Resistive and Cardiovascular Exercise During the First Year Post Discharge

For this project,our objective is to improve rehabilitative outcomes for children with burns >30% total body surface area burned by utilizing an in-house outpatient rehabilitation program, with or without the use of anabolic agents (oxandrolone, Ketoconazole, or propranolol). The supervised exercise program has shown to be effective in ameliorating effects of the hypermetabolic response. We will assess the effectiveness of combining the anabolic agents and the exercise program with the expectation that the effects will be additive and will improve linear growth, bone mass, muscle strength, lean body mass, physical functioning and general well-being.